alpha-Arbutin CAS NO.84380-01-8

Characteristics 1. The more effective, faster and safer approach to skin lightening, minimizes live spots. 2. Promote lightening and an even skin tone on all skin types. 3. Block epidermal melanin biosynthesis by inhibiting enzymatic oxidation of Tyrosine and Dopa. 4. Higher stability and efficacy than β- form in the related beta-arbutin. SPECIFICATION Appearance: White crystalline powder Melting point(°C): 198.0-201.0 Content: ≥99.5% pH(1%): 5.0-7.0 Loss on drying: ≤0.5% Optical rotation: +180±6° Hydroquinone: not more than 10ppm Heavy metals: <20ppm Arsenic: <20 Microbial count: <100CFU/g

Arbutin is a naturally occuring derivative of hydroquinone found in the leaves of cranberry, bearberry, and blueberry shrubs, most types of pears, and many other plants. Arbutin may inhibit melanogenesis by affecting tyrosinase activity. 

Arbutin has been used in the treatment of disorders of hyperpigmentation such as postinflammatory hyperpigmentation caused by acne, trauma, allergic reactions, infections, injuries, phototoxic reactions, reactions to medications, reactions to cosmetics, and inflammatory diseases. 

Arbutin concentration protocols for skin whitening have not yet been established. Low concentrations have no effect, while high concentrations of about 5% or more can be as irritating as hydroquinone and may potentially result in unexpected hyperpigmentation (darkening).